Worlds fatest Man
After reaching a peak weight of around 597 kg (1,320 lb) he had been unable to leave his bed since 2001.
Uribe is shown here at around his peak weight:
Uribe lost approximately 400 lbs (one third of his body weight) with the help of doctors and nutritionists, and by following the Zone diet.
Uribe, who is also known as Xavier, drew worldwide attention when he appeared on the Televisa television network in January 2006, but turned down offers for gastric bypass surgery in Italy.
In March 2007, Uribe set a goal to lower his weight to 120 kg (260 lb). Uribe has also been featured on The World's Heaviest Man, a television documentary about his bedridden life and attempts to lose weight.
By October 26th, 2008, Uribe had reduced his weight to 360 kg (790 lb). His weight loss efforts continue.
In mid 2009, it was falsely reported that Manuel had died.
Manuel Uribe is on a quest to shed another 225 kg (500 lb)
Doctors Mystified by Case of World's Thinnest Woman
|Lizzie Velasquez is a question mark for doctors|
Texas native Lizzie Velasquez, 21, is thinner than anyone thought possible. She spends her days wolfing down burgers, fries and cake, consuming more than three times the normal calorie requirements. Doctors can't explain how she can be so underweight and still alive.
Sultan Kosen, 29, suffers from acromegaly — a condition triggered by a tumour in the pituitary gland.
It leads to over-production of growth hormones, which can cause gigantism if it starts before puberty.
But Turkish Kosen seems to have been helped by scientists at the university of Charlottesville, Virginia, US.
He began treatment in May 2010, when he was placed on a new medication that helps control the production of growth hormone.
Medic Mary Lee Vance said: "Treating someone 8ft 3in tall is no different from treating someone 5ft 10in tall. The important thing is to stop the production of the excess growth hormone."
Around three months ago, Kosen's doctors in Turkey said he had finally stopped growing.
It's hard work being this short: 21.5inch-tall Nepalese farmer, 72, is confirmed as world's smallest man
A 72-year-old Nepalese man who made big claims to being the smallest man in the world has finally been confirmed as a record breaker.
A doctor and Guinness World Records official headed to Nepal to measure Chandra Bahadur Dangi to confirm his height of 21.5 inches (54.6 centimeters), shorter than the length of a broadsheet newspaper, where they declared him the world's shortest person.
On Sunday, Guinness presented Dangi with two certificates for being the world's shortest living man and the world's shortest person ever recorded in Guinness' 57-year history.
Dangi lives in a remote mountain village in Nepal and says he now wants to travel across the country and abroad.
He overtook the previous shortest man Junrey Balawing of the Philippines, who is 23.5 inches (60 centimeters) tall.
He had claimed the title last year from Khagendra Thapa Magar, 18, whose height is 26 inches tall.